In the present study, formulation of hard gelatin capsule containing granules of Losartan potassium, an antihypertensive drug was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance. Advantages of hard gelatin capsule are rapid drug release possible, flexibility of formulation and sealed hard gelatin capsules are good barriers to atmospheric oxygen. The basic aim of this work is to produce immediate release action of drug from the hard gelatin capsule containing granules of Losartan potassium. Formulations were prepared using wet granulation method and then the formulations are filled into empty hard gelatin capsules for the dissolution studies. The prepared granules were evaluated for percentage yield, angle of repose, bulk density, tapped density, Hausner’s ratio and Carr’s index. The hard gelatin capsule containing granules of losartan potassium were also evaluated for disintegration time, drug content and in-vitro drug release. Stability study shows that there was no significant change in disintegration time, drug content and in-vitro drug release of the formulation. Thus, formulation was considered optimized formulation for immediate release of Losartan potassium.
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